Name: Entinostat (MS-275,SNDX-275)
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Entinostat (also known as MS-275 or SNDX-275), a derivative of 2-aminophenyl benzamides, is a potent and orally-available inhibitor of histone deacetylases (HDACs), a family of enzymes associated with a variety of well-characterized cellular oncogenes and tumor suppressors, that potently inhibits class I HDACs, including HDAC1, HDAC3 and HDAC8, with values of 50% inhibition concentration IC50 of 0.368 μM, 0.501 μM and 63.4 μM respectively. Entinostat has been widely investigated for the treatment of cancer, in which results have shown the in vitro anti-proliferative activity of entinostat in a wide range of human cancer cell lines, including breast, colon, lung, myeloma, ovary, pancreas, prostate and leukemia.
- Properties
  - Alternative Name
    
    MS-275,SNDX-275, MS 275, MS-27-275, SNDX275, Histone Deacetylase Inhibitor I, MS27-275; pyridin-3-ylmethyl N-[[4-[(2-aminophenyl)carbamoyl]phenyl]methyl]carbamate
    
    CAS Number
    
    209783-80-2
    
    Molecular Formula
    
    C21H20N4O3
    
    Molecular Weight
    
    376.4
    
    Appearance
    
    A solid
    
    Purity
    
    99.60%
    
    Solubility
    
    insoluble in H2O; ≥18.8 mg/mL in DMSO; ≥7.4 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Wang MH, Wu CH, et al. "Nerve-mediated expression of histone deacetylases regulates limb regeneration in axolotls." Dev Biol. 2019 May 15;449(2):122-131. PMID:30826398
    2. Manna PR, Ahmed AU, et al. "Overexpression of the steroidogenic acute regulatory protein in breast cancer: Regulation by histone deacetylase inhibition." Biochem Biophys Res Commun. 2019 Feb 5;509(2):476-482. PMID:30595381
    3. Bagnall NH, Hines BM, et al. "Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina." Int J Parasitol Drugs Drug Resist. 2017 Apr;7(1):51-60. PMID:28110187

Entinostat (MS-275,SNDX-275)

Entinostat (MS-275,SNDX-275)

Background

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