Name: Cathepsin G Inhibitor I
Price: 541.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    IC50: 53 nM Cathepsin G (EC 3.4.21.20, chymotrypsin-like proteinase, neutral proteinase) is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSG gene. Cathepsin G Inhibitor I is a potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G. In vitro: Cathepsin G Inhibitor I shows reversible, competitive inhibition with IC50 and Ki values of 53 ± 12 (N = 10) and 63 ± 14 nM (N = 5), respectively. Another attribute of Cathepsin G Inhibitor I relates to its selectivity vs other serine proteases. It weakly inhibits chymotrypsin (Ki = 1.5 ± 0.2 μM), and poorly inhibits (<50% inhibition at 100 μM) thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase [1]. In vivo: Cathepsin G Inhibitor I is currently in in-vitro investigation and no animal in vivo study is ongoing [1]. Clinical trial: Cathepsin G Inhibitor I is currently in the preclinical development and no clinical trial is ongoing.
- Properties
  - Alternative Name
    
    [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid
    
    CAS Number
    
    429676-93-7
    
    Molecular Formula
    
    C36H33N2O6P
    
    Molecular Weight
    
    620.64
    
    Appearance
    
    A solid
    
    Purity
    
    95.56%
    
    Solubility
    
    ≥10.35 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only