Decitabine- Bio-X - Amerigo Scientific

- Overview
  - A synthetic cytosine analogue that incorporates into DNA and prevents DNA methylation via DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibition. Demonstrated potent anti-leukaemic effects attributed to cell cycle arrest and induction of apoptosis. Has anti-growth effects on solid tumor cell lines.
    
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- Properties
  - Categories
    
    Enzyme Modulators
    
    Alternative Name
    
    Decitabine; 4-Amino-1-(2-deoxy-b-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 5-Aza-2-deoxy-D-cytidine; 2?-Deoxy-5-azacytidine
    
    CAS Number
    
    2353-33-5
    
    Molecular Formula
    
    C8H12N4O4
    
    Molecular Weight
    
    228.21 g/mol
    
    MDL Number
    
    MFCD00043011
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Bender et al (1998). Inhibition of DNA methylation by 5-aza-2-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Research. 58(1):95-101.
    Momparler (2005). Pharmacology of 5-Aza-2-deoxycytidine (decitabine). Seminars in Hematology. 42(3 Supplements 2): S9-16.
    Shin et al (2012). Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation. International Journal of Oncology, 41(3):910-8.