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dBET1

dBET1

Catalog Number:
PTC1441497INV
Mfr. No.:
V3476
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      • Overview

        • dBET1 is a novel, potent, and competitive CRBN-based BET degrader (PROTAC) with an IC50 of 20 nM. It exhibits high selectivity among 7,429 proteins, only the expression of the oncoproteins MYC and PIM1, as well as BRD2, BRD3 and BRD4 are significantly downregulated by dBET1 treatment. BET degradation with dBET1 will likely reduce expression of pro-inflammatory genes in in vivo neuroinflammatory models associated with microglial/immune cell activation.

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      • Properties
        • Categories
          PROTACs
          CAS Number
          1799711-21-9
          Molecular Formula
          C38H37CLN8O7S
          Molecular Weight
          785.27
          Purity
          ≥98%
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
          Shipping
          Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
          SMILES
          CC(N(C1C2=NN=C(C)N2C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=N1)CCCCNC(COC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)=O)=O

          * For research use only

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