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dBET6

dBET6

Catalog Number:
PTC1441498INV
Mfr. No.:
V3477
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      • Overview

        • dBET6 is a novel, highly potent, selective and cell-permeable chemical degrader of BET bromodomain proteins based on PROTAC technology with an IC50 of 14 nM. It has potential antitumor activity. In contrast to the selective effect of bromodomain inhibition on transcription, BET degradation prompts a collapse of global elongation that phenocopies CDK9 inhibition. Notably, BRD4 loss does not directly affect CDK9 localization. These studies, performed in translational models of T cell leukemia, establish a mechanism-based rationale for the development of BET bromodomain degradation as cancer therapy.

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      • Properties
        • Categories
          PROTACs
          CAS Number
          1950634-92-0
          Molecular Formula
          C42H45CLN8O7S
          Molecular Weight
          841.37
          Purity
          ≥98%
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
          Shipping
          Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
          SMILES
          O=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N41

          * For research use only

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