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Overview
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1-(2,2-Dimethylhydrazide)butanedioic acid; N-(dimethylamino)succinamic acid,
Daminozide is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 mM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50>100 mMPlease contact us at for specific academic pricing.
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