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Overview
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2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride
BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 µM) as well as GLP HMTase (IC50 = 38 µM) leading to a decrease in H3K9Me2 (histone H3 lysine 9 methylation) in vitro. It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming.BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells. It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells.Please contact us at for specific academic pricing.
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