Cytochrome c - pigeon (88-104) - Amerigo Scientific

- Overview
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    Background
    
    H-Lys-Ala-Glu-Arg-Ala-Asp-Leu-Ile-Ala-Tyr-Leu-Lys-Gln-Ala-Thr-Ala-Lys-OH
    The I-Ek-restricted T cell response to Cytochrome c - pigeon (pcyt c) is specific for a peptide within the COOH-terminal sequence 88-1041.
    The minimal length of the pcyt c peptide required for T cell stimulation is the COOH-terminal sequence containing residues 95-104. However, the addition of residues to the NH2 terminus of residue 95 increases the antigenic potency of the peptide; the maximal response is induced by pcyt c 88-1042.
    The substitution of any residue between 95 and 104 of the cytochrome c peptide changed the antigenic potency of the peptide for at least one of the hybridomas3.
    
    1. Schwartz, R. H. 1985. T lymphocyte recognition of antigen in association with gene products of the MHC. Annu. Rev. Immunol. 3:237.
    2. Bhayani, H., F. R. Carbone, and Y. Paterson. 1988. The activation of pigeon cytochrome c-specific T cell hybridomas by antigenic peptides is influenced by non-native sequences at the amino terminus of the determinant. J. Immunol. 141:377.
    3. Bhayani, H., Y. Paterson. 1989. Analysis of peptide binding patterns in different major histocompatibility complex/t cell receptor complexes using pigeon cytochrome c-specific t cell hybridomas.
- Properties
  - Categories
    
    Triggers T Cell response
    
    Alternative Name
    
    H2N-Lys-Ala-Glu-Arg-Ala-Asp-Leu-Ile-Ala-Tyr-Leu-Lys-Gln-Ala-Thr-Ala-Lys-OH
    
    CAS Number
    
    86579-06-8
    
    Molecular Formula
    
    C84H144N24O25
    
    Molecular Weight
    
    1890.19
    
    Appearance
    
    A solid
    
    Purity
    
    98.58%
    
    Solubility
    
    ≥189 mg/mL in DMSO; insoluble in EtOH; ≥15.6 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCC(C)C(C(=O)NC(C)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CCCCN)N
    
    * For Research Use Only