Cy3.5 hydrazide (non-sulfonated)

- Overview
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    Background
    
    Cy3.5 hydrazide is a near infrared fluorophore that can react with various carbonyl groups in biomolecules which are generated after oxidative stress or deamination of proteins. In addition, aldehyde moieties can be produced by periodate oxidation of sugar residues of glycoproteins, such as antibodies that can then be oxidized by sodium periodate and labeled with Cy3.5 hydrazide to form Cy3. 5 labeled antibodies. For biomolecule labeling, the labeling regent has low aqueous solubility, using of organic co-solvent to dissolve this molecular is necessary for efficient reaction. First, Cyanine dye should be dissolved in organic solvent and then added to a solution of biomolecule in appropriate aqueous buffer.
- Properties
  - Categories
    
    carbonyl-reactive dye
    
    Alternative Name
    
    3-(6-hydrazinyl-6-oxohexyl)-1,1-dimethyl-2-((1E,3E)-3-(1,1,3-trimethyl-1H-benzo[e]indol-2(3H)-ylidene)prop-1-en-1-yl)-1H-benzo[e]indol-3-ium chloride hydrochloride
    
    Molecular Formula
    
    C38H44Cl2N4O
    
    Molecular Weight
    
    643.69
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥64.4 mg/mL in DMSO; insoluble in H2O; ≥33.33 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CN1C2=CC=C3C=CC=CC3=C2C(C)(C)/C1=C\C=C\C4=[N+](CCCCCC(NN)=O)C5=CC=C(C=CC=C6)C6=C5C4(C)C.Cl.[Cl-]
    
    * For Research Use Only