Name: ZCL278
Price: 223.00 USD

- Overview
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    Background
    
    ZCL278 is a selective inhibitor of Cdc42 with Kd value of 11.4 μM [1].
    Cell division control protein 42 homolog (Cdc42) is a small GTPase that belongs to the Rho family and plays an important role in regulating diverse cellular functions including cell morphology, endocytosis, migration, and cell cycle progression [2].
    ZCL278 is a potent Cdc42 inhibitor and has a different selectivity with the reported Cdc42 inhibitor ML141. When tested with human metastatic prostate cancer PC-3 cells, ZCL278 showed inhibitory function on Rac/Cdc42 phosphorylation and the function increasing as the more-treated time. In cortical neurons, ZCL278 treatment suppressed neuronal branch number and inhibited growth cone motility at the dose of 50 μM for 5 or 10 min. Treated serum-starved Swiss 3T3 fibroblasts Cdc42 activator following administration of ZCL278 at the dose of 50 μM for 1 h exhibited a significant decrease (nearly 80%) in GTP-Cdc42 and disrupted perinuclear distribution of active Cdc42. [1]. When tested with rat cerebellar granule neurons (CGNs), pre-treated with ZCL278 before exposed to NaAsO2 increased cell viability in a dose-dependent manner (20, 50 and 100μM) [3].
    
    [1]. Friesland, A., et al., Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility. Proc Natl Acad Sci U S A, 2013. 110(4): p. 1261-6.
    [2]. Selamat, W., et al., The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity. PLoS One, 2015. 10(6): p. e0129634.
    [3]. Liu, X., et al., Neuroglobin Plays a Protective Role in Arsenite-Induced Cytotoxicity by Inhibition of Cdc42 and Rac1GTPases in Rat Cerebellar Granule Neurons. Cell Physiol Biochem, 2015. 36(4): p. 1613-1627.
- Properties
  - Alternative Name
    
    2-(4-bromo-2-chlorophenoxy)-N-[[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]carbamothioyl]acetamide
    
    CAS Number
    
    587841-73-4
    
    Molecular Formula
    
    C21H19BrClN5O4S2
    
    Molecular Weight
    
    584.89
    
    Appearance
    
    A solid
    
    Purity
    
    97.00%
    
    Solubility
    
    ≥29.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Fray MA, Charpentier JC, et al. "Vav2 lacks calcium entry-promoting scaffolding functions unique to Vav1 and inhibits T cell activation via Cdc42." J Cell Sci. 2020;jcs.238337. PMID:31974114
    2. Yang Yang, Kaiyuan Zhang, et al. "SVCT2 Promotes Neural Stem/Progenitor Cells Migration Through Activating CDC42 After Ischemic Stroke." Front. Cell. Neurosci. 19 September 2019.
    3. Ye Y, Li SL, et al. "Exosomal miR-141-3p regulates osteoblast activity to promote the osteoblastic metastasis of prostate cancer." Oncotarget. 2017 Oct 24;8(55):94834-94849. PMID:29212270

ZCL278

ZCL278

Background

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