Name: Compstatin
Price: 298.00 USD

- Overview
  - C3 convertase inhibitor.
    Compstatin, a cyclic tridecapeptide, discovered from a phage-display library, is a highly potent and selective complement component 3 (C3) inhibitor, binding to C3, C3b, and C3c, but not to C3d. Compstatin binds to C3 in a reversible manner and inhibits proteolytic cleavage by C3 convertase to the proteins C3a and C3b and consequent activation of classical and alternative complement pathways. Compstatin accordingly acts as a complement inhibitor and prolongs graft survival and reduces hyperacute rejection of pig kidneys perfused with human blood, and inhibits in vivo heparin/protamine induced complement activation in primates.
    
    Please contact us for availability.
    
    Please contact us at for specific academic pricing.
- Properties
  - Categories
    
    Peptides
    
    Molecular Formula
    
    C66H99N23O17S2
    
    Molecular Weight
    
    1550.77
    
    Appearance
    
    Freeze dried solid
    
    Purity
    
    >95% by HPLC
    
    Solubility
    
    Soluble to 2 mg/ml in water
    
    Other Properties
    
    Sequence: H-Ile-*Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-*Cys-Thr-NH2 (disulphide bridge between cysteines 2 and 12),ICVVQDWGHHRCT-NH2
    Modification: C-terminal amide, disulphide bridge between cysteines 2 and 12
    
    Storage
    
    Store dry, frozen and in the dark
    
    * Please note: this product can only be supplied to registered research and development facilities, and may be used for in vitro research use only, not for administration to humans or animals.

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