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Overview
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Dextran sulfate sodium salt (DSS) is a polyanionic derivative of dextran produced by the esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. DSS has several characteristics: 1) polyanionic complex, soluble in water, forming a colorless aqueous solution; 2) high purity and good stability; 3) can be degraded naturally. Inflammatory bowel disease (IBD) is a chronic, relapsing gastrointestinal infection that increases the risk of intestinal tumors, mainly including UC and Crohn disease (CD). In 1985, after the hamster ulcerative colitis model was first prepared by using DSS, a large number of studies have proved that the DSS colitis model is similar to human ulcerative colitis. The histological features, clinical manifestations, disease site, and cytokine proliferation of the DSS colitis model are very similar to human ulcerative colitis (UC). The modeling conditions and operation methods of this model are simple, the expenditure is very cheap, the repeatability is good, and it is easy to master and popularize. The DSS concentration and dosing time can be adjusted according to the experimental purpose to establish acute, chronic, and acute-chronic alternation models.
Features
• High purity, water-soluble, and stable – forms a clear aqueous solution with reliable quality.
• Biodegradable – naturally degradable, safe for long-term studies.
• Easy to use – simple protocols with high repeatability.
• Versatile UC model induction – dose-dependent UC symptoms, closely resembling human UC.
• Multi-species applicability – effective in mice, rats, zebrafish, pigs, fruit flies, etc.
• Widely used in IBD/CAC research – especially suitable for colitis and colitis-associated cancer models (with AOM).Please contact us at for specific academic pricing.
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