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Overview
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Coenzyme A (CoA) is an indispensable and ubiquitous metabolic cofactor for all organisms. It is synthesized in an evolutionarily conserved pathway by enzymatic conjugation of cysteine, pantothenate (Vitamin B5), and ATP. This unique chemical structure allows CoA to employ its highly reactive thiol group for diverse biochemical reactions. CoA is involved in approximately 9% of all metabolic pathways, including the tricarboxylic acid (TCA) cycle, fatty acid regulation, amino acid synthesis, and lipid metabolism (Leonardi et al., 2005; Daugherty et al., 2002).
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- Properties
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Overview