Co-trimoxazole ReadyMade™ Solution

Co-trimoxazole ReadyMade™ Solution is provided as a sterile-filtered solution formulated in DMSO at a concentration of 100 mg/ml. Trimethoprim-Sulfamethoxazole) is a combination of two anti-infectives, trimethoprim and sulfamethoxazole, in a ratio of one part trimethoprim to five parts sulfamethoxazole. A syngergistic effect has been demonstrated both in vitro and in animal studies, as they inhibit successive steps in the folate synthesis pathway. Co-trimoxazole belongs to the sulfonamide class and is bactericidal and antiparasitic in nature, useful against bacteria causing respiratory tract infections It also has immunomodulatory and anti-inflammatory properties and may be studied to ameliorate the cytokine storm syndrome associated with severe COVID-19 disease.

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Background

Co-trimoxazole intereferes with bacterial folic acid metabolism by blocking nuelcotide biosynthesis. Trimethoprim binds to dihydrofolate reductase (DHFR) which blocks the reduction of dihydrofolic acid (DHF) to detrahydrofolic acid (THF) and gives the compound its antimicrobial effect. Sulfamethoxazole interferes with nucleic acid synthesis by clocking conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net result is to inhibit thymine synthesis which in turn prevents the synthesis of bacterial DNA.