Clindamycin

- Overview
  - Clindamycin is a broad-spectrum antibiotic and antiparasitic agent. It is a semi-synthetic derivative of Lincomycin, a natural lincosamide from Streptomyces lincolnensis. It is obtained by chloride substitution of the exocyclic sugar hydroxy group for improved pharmacodynamics, and was first announced in 1966. Clindamycin is freely soluble in water.
    
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    Background
    
    Clindamycin has a bacteriostatic effect, acts by reversible binding to the 50S rRNA of the large bacterial ribosome subunit, preventing ribosomal translocation and thus protein synthesis.
- Properties
  - CAS Number
    
    18323-44-9
    
    Molecular Formula
    
    C18H33CIN2O5S
    
    Molecular Weight
    
    425.0
    
    Appearance
    
    White solid
    
    Solubility
    
    Freely soluble in water. Soluble in ethanol, methanol, DMF and DMSO.
    
    Other Properties
    
    Source: semi-synthetic
    Purity Level: >99% by HPLC
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Clindamycin has broad-spectrum activity against Gram-positive and Gram-negative anaerobic bacteria, in addition to protozoa.
    
    Eukaryotic Cell Culture Applications: HIV-infected MOLT3 cells were incubated with increasing concentrations of Clindamycin and did not result in increased cell death compared to uninfected control cells (Wijsman et al, 2013). The effects of Clindamycin and its metabolites on mammalian cell lines (mouse leukemia L1210, human oral carcinoma KB, human acute myelogenous leukemia RPMI 6410, and human lymphocyte RPMI 1788) were evaluated. Metabolites clindamycin sulfoxide and clindamycoase were nontoxic, wherease N-demethyl clindamycin showed cytotoxic effects in culture (Li LH et al (1977).