CLIA Validated Human MGMT Methylation Assay in intron 1

• CLIA Validated validated
• Compatible with targeted bisulfite NGS, bisulfite Pyrosequencing, and MS-HRM.
• Provide % methylation at single base resolution.
• Reproducable, sensitive & quick turn-around time.

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Background

Gene methylation is a DNA-based gene expression regulation method. Methylation levels in gene promoter regions can be aberrant or elevated in cancer (hypermethylated). This epigenetic change to DNA prevents the gene from performing its function, resulting in the protein encoded by the gene not being created or being produced at a low level.

O6-methylguanine-DNA methyltransferase (MGMT) is an important DNA repair enzyme in a healthy person. During the progression of cancer, this gene’s activity or function is usually lost. When the MGMT gene or function is lost, an individual is more vulnerable to DNA damage and tumor growth. However, once the cancer has progressed, the presence or absence of MGMT activity is no longer a factor.