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Overview
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Chlorogenic acid (CGA), the conjugate acid of chlorogenate, is the ester of trans-caffeic acid and (-)-quinic acid. CGA is produced by formal condensation of the carboxy group of trans-caffeic acid with the 3-hydroxy group of quinic acid. It is the predominant class of phenolic acids found in coffee and coffee beans, known as an intermediate metabolite in the biosynthesis of lignin. CGA exhibits many biological properties including antibacterial, antioxidant, and anticarcinogenic activities. Most importantly, CGA exerts an important role as anantidiabetic agent through regulation of the whole body and tissue-specific glucose metabolism.
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