Chlorin e6

- Overview
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    Background
    
    Chlorin e6 (Ce6) is a second-generation photosensitizer with antitumor activity when used in conjunction with irradiation.
    In a mouse model of implanted fibrosarcoma, Ce6 (2.5-10 mg/kg, i.v. with irradiation at 50-200 J/cm2) led to complete tumor loss following varying levels of irradiation[1].
    A formulation including Ce6 was tested in a Phase I clinical study for patients with bronchogenic early superficial squamous cell carcinoma with positive results (40 mg/m2, i.v. with laser irradiation at 100 J/cm2)[2]. The same dosing paradigm in a Phase II clinical trial for early stage lung cancer patients led to a complete response in 82.9% of patients[3].
    
    [1]. Katsumi T A, Aizawa K, Kuroiwa Y, et al. Photodynamic therapy with a diode laser for implanted fibrosarcoma in mice employing mono-L-aspartyl chlorin E6. Photochem. Photobiol, 1996, 64(4): 671-675.
    [2]. Furukawa K, Okunaka T, Tsuchida T. A phase I clinical study of photodynamic therapy for early stage lung carcinoma using ME2906 and a diode laser system. Porphyrins, 1998, 7: 199-206.
    [3]. Kato H, Furukawa K, Sato M, et al. Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer, 2003, 42(1): 103-111.
- Properties
  - Alternative Name
    
    Ce6; (7S,8S)-3-carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphine-7-propanoic acid
    
    CAS Number
    
    19660-77-6
    
    Molecular Formula
    
    C34H36N4O6
    
    Molecular Weight
    
    596.67
    
    Purity
    
    Purity ≥90.00%
    
    Solubility
    
    ≤30 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CC1=C2NC(/C(CC(O)=O)=C(N=C3/C=C4N/C(C(C=C)=C\4C)=C\C5=N/C(C(CC)=C5C)=C\2)/[[email protected]@H](CCC(O)=O)[[email protected]@H]3C)=C1C(O)=O
    
    * For Research Use Only