Cefteram pivoxil

- Overview
  - Cefteram pivoxil is a third generation cephalosporin antibiotic. Cefteram pivoxil contains a pivoxil group which increases lipophilicity. Cefteram pivoxil is freely soluble in ethanol, acetonitrile, methanol, and chloroform.
    
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    Background
    
    Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
- Properties
  - CAS Number
    
    82547-81-7
    
    Molecular Formula
    
    C22H27N9O7S2
    
    Molecular Weight
    
    593.64
    
    Appearance
    
    Off-white or light yellow powder
    
    Other Properties
    
    Source: Synthetic
    Water Content (Karl Fischer): ≤2.0%
    Assay: ≥98.0% (as is)
    Optical Rotation: +35° - +43°
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Like many third generation cephalosporins, cefteram is mostly active against gram negative bacteria especially those which cause meningitis and gonorrhea.