Ceftazidime, Delta-3-Isomer, EvoPure®

Ceftazidime, Delta-3-Isomer, EvoPure® is an isomer and degradation product of Ceftazidime. It can be used as a reference standard to trace Ceftazidime. This isomer was formerly known as Delta-2.
Ceftazidime is a broad-spectrum, third-generation, β-lactam cephalosporin that interferes with bacterial cell wall synthesis. Patented in 1979 by Glaxo Group, Ceftazidime came into commercial use in 1984. It is sparingly soluble in aqueous solution.
EvoPure® products are highly purified compounds that can be used for in vitro applications like analytical reference standards, upstream pharmaceutical product manufacturing, gene selection, and toxicity studies.

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Background

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases, however, Ceftazidime is stable in the presence of β-lactamases.