Name: Cefoperazone Sodium/Sulbactam Sodium (2:1)
Price: 182.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid-encoded β-lactamases.
- Properties
  - CAS Number
    
    62893-20-3 (Cefoperazone sodium); 69388-84-7 (Sulbactam Sodium
    
    Molecular Formula
    
    C25H26N9NaO8S2 (Cefoperazone Sodium); C8H10NNaO5S (Sulbactam Sodium)
    
    Molecular Weight
    
    667.65 (Cefoperazone Sodium); 255.22 (Sulbactam Sodium)
    
    Appearance
    
    White to almost white powder
    
    Solubility
    
    Soluble in water
    
    Other Properties
    
    Source: Semi-synthetic
    
    Storage
    
    2-8°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Cefoperazone Sodium/Sulbactam Sodium (2:1) has a broad-spectrum activity, effective against a wide variety of Gram-positive and Gram-negative bacteria. The antibacterial activity is largely due to Cefoperazon, as the Sulbactam has little intrinsic antibacterial activity except for stains of Aceinetobacter and Neisseria, but it is active against the β-lactamase enzymes of most Staphylocci and Gram-negative bacilli including ESBLs.
    
    Microbiology Applications: In vitro activity of Cefoperazone Sodium/Sulbactam Sodium was tested agaisnt 94 ceftazime-resistant strains isolated from patients in critical care units. Of the pathogens studied, Acetinetobacter baumanii, Pseudomonas aeruginosa, and Klebsiella pneumoniae made up 80% of the pathogens studied. The MIC90 for Klebsiella was 12 mg/L (range 1.5-16 mg/L) indicating that it may be useful for ceftazidime-resistant extended-spectrum β-lactamase (ESBL)-producing Klebsiella (Lim and Halijah, 2001).