Name: Calpeptin
Price: 180.00 USD

- Overview
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    Background
    
    IC50: 5 nM for human calpain 1
    Calpeptin is a calpain inhibitor.
    As a calcium-dependent intracellular cysteine protease, calpain plays an key role in various cellular processes including cell differentiation, growth and apoptosis. In rheumatoid arthritis patients, over-expression of calpains are observed in arthritic synovial fluid and are thought to play critical roles in various cellular processes.
    In vitro: Calpeptin reduced production of TGF-b1, IL-6, angiopoietin-1 and collagen synthesis from lung fibroblasts. Calpeptin also reduced both angiopoietin-1-dependent migration and IL-6-dependent proliferation of the cells, which could be the underlying mechanism of the preventive effect of Calpeptin on pulmonary fibrosis [1].
    In vivo: The preventive effect of calpeptin has been examined on bleomycin-induced pulmonary fibrosis in mice. Histological examinations and quantitative measurements of related proteins in bleomycin-treated mouse lung tissues with or without calpeptin were performed. Calpeptin histologically ameliorated bleomycininduced pulmonary fibrosis in mice. Results showed that calpeptin decreased the expression of IL-6, TGF-b1, angiopoietin-1 and collagen type Ia1 mRNA in mouse lung tissues [1].
    Clinical trial: N/A
- Properties
  - Alternative Name
    
    benzyl N-[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]carbamate
    
    CAS Number
    
    117591-20-5
    
    Molecular Formula
    
    C20H30N2O4
    
    Molecular Weight
    
    362.47
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥90.00%
    
    Solubility
    
    insoluble in H2O; ≥87.6 mg/mL in DMSO; ≥96.6 mg/mL in EtOH
    
    Storage
    
    Desiccate at 4°C
    
    * For Research Use Only