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Overview
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Calpain and cathepsin B inhibitor.
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B with Ki values of 10 and 25 nM respectively, but does not have any effect on trypsin-like serine proteases. MDL 28170 rapidly penetrates the blood-brain barrier following systemic administration and demonstrates neuroprotective effects in vivo.
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Overview