BSA-DM1 (Mertansine) Conjugate

DM1 (mertansine) is a thiol-containing derivative of maytansine. It binds to tubulin and inhibits the assembly of microtubules. DM1 is used to prepare ADCs (antibody-drug conjugates), such as trastuzumab emtansine (abbreviated as T-DM1). This BSA-DM1 conjugate is designed with similar linker chemistry as T-DM1 and is synthesized for our customers' usage in immunization or immunoassay. Maleimide functional groups are first introduced to the BSA followed by a reaction of the maleimide group with the thiol of DM1 to form the BSA-DM1 conjugate.

The final conjugate is lyophilized from phosphate buffered saline containing sugar-based stabilizer for easy shipping and storage.

The product is sold as either 1 vial of 1 mg (Cat# CM52110-1MG) or 5 vials of 1 mg (Cat# CM52110-5MG).

• Chemical Information
Chemical name: BSA-DM1 (Mertansine) Conjugate
Chemical formula: N/A
Molecular weight: 70KDa; CAS number: N/A

• Specification
Physical appearance: white to off-white preservative-free lyophilized powder in a 2.0 mL centrifuge tube
Storage temp.: -20 °C
Purity: ≥ 99 % of conjugates by HPLC
Amount of DM1 loaded per BSA molecule: ~4

Please contact us at for specific academic pricing.