Login / Register
0

BRD4 degrader AT1

BRD4 degrader AT1

Catalog Number:
PTC1441492INV
Mfr. No.:
V3581
Price:
Inquiry
  • Size:
    Quantity:
    Add to Cart:
    Add to Cart
      • Overview

        • BRD4 degrader AT1 is a novel, potent and highly selective PROTAC-based BRD4 degrader (Kd = 44 nM for Brd4BD2 in cells) with anticancer activity. Inducing macromolecular interactions with small molecules to activate cellular signaling is a challenging goal. PROTACs (proteolysis-targeting chimeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase-PROTAC-target species and its impact on target degradation selectivity remain elusive.

          Please contact us at for specific academic pricing.

      • Properties
        • Categories
          PROTACs
          CAS Number
          2098836-45-2
          Molecular Formula
          C48H58CLN9O5S3
          Molecular Weight
          972.68
          Purity
          ≥98%
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
          Shipping
          Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
          SMILES
          CC1=C(C2=CC=C(CNC([C@H]3N(C([C@@H](NC(C)=O)C(C)(SCCCCCCNC(C[C@H]4C5=NN=C(C)N5C(SC(C)=C6C)=C6C(C7=CC=C(Cl)C=C7)=N4)=O)C)=O)C[C@H](O)C3)=O)C=C2)SC=N1

          * For research use only

    We Also Recommend

    BSJ-03-123

    BSJ-03-123

    BSJ-03-123

    BSJ-03-123

    BSJ-4-116

    BSJ-4-116

    CDK9 Antagonist-1

    CDK9 Antagonist-1

    Note: If you don't receive our verification email, do the following:

    • Confirm that you entered your email address correctly.
    • Check if the email is in your spam or junk folder.
    • Or you may contact us at .
    • Products
    Amerigo Scientific
    Support
    Contact Us
    Copyright © Amerigo Scientific. All rights reserved.