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BSJ-03-123

BSJ-03-123

Catalog Number:
PTC1441493INV
Mfr. No.:
V3439
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      • Overview

        • BSJ-03-123 is a novel, potent cyclin-dependent kinase 6 (CDK6)-selective small-molecule degrader (PROTAC: proteolysis targeting chimera). It is a phthalimide-based degrader that exploits protein-interface determinants to achieve proteome-wide selectivity for the degradation of cyclin-dependent kinase 6 (CDK6). Pharmacologic CDK6 degradation targets a selective dependency of acute myeloid leukemia cells, and transcriptomics and phosphoproteomics profiling of acute degradation of CDK6 enabled dynamic mapping of its immediate role in coordinating signaling and transcription.

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      • Properties
        • Categories
          PROTACs
          CAS Number
          2361493-16-3
          Molecular Formula
          C47H56N10O11
          Molecular Weight
          937.01
          Purity
          ≥98%
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
          Shipping
          Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
          SMILES
          O=C(NCCOCCOCCOCCN1CCN(C2=CC=C(NC3=CC4=C(C=N3)C(C)=C(C(C)=O)C(N4C5CCCC5)=O)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O

          * For research use only

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