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Pyrvinium Pamoate

Pyrvinium Pamoate

Catalog Number:
FC01366356APE
Mfr. No.:
APE-B8393
Price:
$180
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      • Overview

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          Background

          Payrvinium pamoate is an ancient anthelmintic used to treat intestinal helminthiasis. As it inhibits the Wnt / β-catenin pathway in certain types of cancer, it has attracted attention as an anticancer drug. In vitro, palmitate pyruvate treatment inhibited AKT-mediated phosphorylation of GSK3β at S9 and reduced the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). In addition, palmitate pyruvate significantly inhibited migration and invasion in vitro.

      • Properties
        • Alternative Name
          Pyrvinium embonate; (E)-2-(2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)vinyl)-6-(dimethylamino)-1-methylquinolin-1-ium 4,4'-methylenebis(3-hydroxy-2-naphthoate)
          CAS Number
          3546-41-6
          Molecular Formula
          C75H70N6O6
          Molecular Weight
          1151.39
          Purity
          98.00%
          Solubility
          insoluble in EtOH; insoluble in H2O; ≥8.6 mg/mL in DMSO
          Storage
          Store at -20°C
          SMILES
          OC1=C(C([O-])=O)C=C2C=CC=CC2=C1CC3=C4C=CC=CC4=CC(C([O-])=O)=C3O.C[N+]5=C6C(C=C(N(C)C)C=C6)=CC=C5/C=C/C7=C(C)N(C8=CC=CC=C8)C(C)=C7.C[N+]9=C%10C(C=C(N(C)C)C=C%10)=CC=C9/C=C/C%11=C(C)N(C%12=CC=CC=C%12)C(C)=C%11

          * For Research Use Only

    Documents

    COA (Certificate Of Analysis)

    MSDS (Material Safety Data Sheet)

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