Name: Biotin Hydrazide
Price: 188.00 USD

- Overview
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    Background
    
    Biotin hydrazide is a biotinyl derivative that can be used as a probe for the determination of protein carbonylation, which is a component of several diseases. Protein carbonylation, an irreversible post translational modification (PTM), is caused by attack of reactive oxygen species (ROS), numerous lipid oxidation products (such as α,β-unsaturated γ-hydroxyalkenals), or nonemzymatic glycation resulting in the loss of protein function. Biotin hydrazide is a preferred carbonyl-reactive probe for its direct reaction and chemistry and no requirement of additional catalysts or reducing agents. Biotin hydrazide exclusively and readily derivatizes carbonyl groups at pH 5.5, which facilitates its use to measure carbonylated proteins in biological samples.
    
    Reference:
    Kenneth Hensley, Kelly S. Williamson. Protein Carbonyl Determination Using Biotin Hydrazide. Methods in Biological Oxidative Stress. Methods in Pharmacology and Toxicology 2003, pp 195-199
    Madian AG, Regnier FE. Proteomic identification of carbonylated proteins and their oxidation sites. J Proteome Res. 2010;9(8):3766-3780.
- Properties
  - Categories
    
    Carbonyl-reactive biotinylation reagent
    
    Alternative Name
    
    (+)-Biotin Hydrazide; Biotin-Hz; Hydrazide Biotin; Biotine Hydrazide; 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanehydrazide
    
    CAS Number
    
    66640-86-6
    
    Molecular Formula
    
    C10H18N4O2S
    
    Molecular Weight
    
    258.3
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in EtOH; ≥12.9 mg/mL in DMSO with gentle warming; ≥2.98 mg/mL in H2O with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C1C2C(C(S1)CCCCC(=O)NN)NC(=O)N2
    
    * For Research Use Only