Name: Biotin-azide
Price: 172.00 USD

- Overview
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    Background
    
    Biotin azide reacts with the terminal alkynes via a copper-catalyzed click reaction, including biomolecules containing alkyne groups through azide-alkyne cycloaddition. Biotin and biotin derivatives can be readily conjugated to various biomolecules through the well-known click chemistry and subsequently detected with streptavidin, avidin or NeutrAvidin biotin-binding protein. Biotin azide can be used to prepare various biotinylated conjugates via Click Chemistry. Click chemistry contains a class of chemical reactions that use bio-orthogonal or biologically unique moieties to label and detect the molecule in mild and aqueous conditions. This reagent allows labeling of various alkynylated molecules, such as DNA, oligonucleotides, and proteins with biotin. Biotin binding to avidin or streptavidin could be used in downstream affinity applications for the isolation of biotinylated molecules or their binding with streptavidin conjugates [1].
    
    Reference:[1] Bruckman M A, Czapar A E, VanMeter A, et al. Tobacco mosaic virus-based protein nanoparticles and nanorods for chemotherapy delivery targeting breast cancer[J]. Journal of Controlled Release, 2016, 231: 103-113.
- Properties
  - Categories
    
    biotinyltation reagent
    
    Alternative Name
    
    N-(3-azidopropyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide
    
    CAS Number
    
    908007-17-0
    
    Molecular Formula
    
    C13H22N6O2S
    
    Molecular Weight
    
    326.42
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥32.6 mg/mL in DMSO; insoluble in H2O; ≥2.51 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    O=C1N[[email protected]@]([H])(CS[[email protected]]2CCCCC(NCCCN=[N+]=[N-])=O)[[email protected]]2([H])N1
    
    * For Research Use Only