BcMag™ One-Step Mammalian Cell DNA Purification Kit

Large-scale purification of high-quality DNA from mammalian cells in sufficient quantities requires an efficient methodology for high sample volumes. Nevertheless, the protocols for most commercially available genomic DNA (gDNA) extraction kits suffer from a tedious binding-washing-elution step, poor integrity, DNA losses, and the use of toxic organic solvents. To overcome these drawbacks, we developed a novel revolutionary one-step DNA purification system based on magnetic beads and negative chromatography, which combines DNA extraction with removing all the PCR inhibitors from the samples without performing DNA isolation and purification steps. BcMag™ One-Step Mammalian Cell DNA Purification Kit allows rapid and efficient purification of genomic DNA from cells. It uses novel negative selection chromatography magnetic beads to quickly capture impurities such as PCR inhibitors from cell lysate (See “PCR inhibitor removal”), leaving the DNA untouched. It reduces the risk of DNA loss and carryover of extraction buffers from the traditional and tedious bind-wash-elute procedure. The purification kit provides a fast and simple method for DNA extraction with only one tube, no liquid transfer, and no requirement for carrier RNA. After preparing the lysates, it enables the processing of 96 samples in less than 15 minutes, with less than 1 minute of hands-on Time.

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