BcMag™ Monomer Avidin Magnetic Beads

BcMag™ Monomer Avidin Magnetic Beads are highly uniform superparamagnetic microspheres coated with high purity density ( 97%) avidin subunit monomer on the surface. Monomeric avidin, derived from the native tetrameric protein, retains the same biotin-binding specificity as native avidin, but its biotin-binding affinity dramatically decreases (kD=~10 -8 M). Therefore, the bound molecules can be easily eluted from the beads by mild elution conditions such as 2mM biotin instead of harsh elution reagents such as 8M guanidine or SDS detergent. The beads perfectly fit into applications such as immunoprecipitation, cell sorting, and rapid single-step capture of biotinylated molecules such as DNA, RNA, antibody, or protein from cell lysates or hybridization reactions. The interaction between avidin (or streptavidin) and biotin exhibits one of the highest known non-covalent interactions). Avidin, streptavidin, monomeric avidin, and their analogs have become powerful tools for probes and affinity ligands for various applications in biochemical assays, diagnosis, affinity purification, and drug delivery.

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