BcMag™ Cleavable Streptavidin Magnetic Beads

BcMag™ Cleavable Streptavidin Magnetic Beads are uniform superparamagnetic microspheres coated with high purity of ( 97%) streptavidin. Since the streptavidin is linked to the beads (particles) through a built-in cleavable disulfide linker, the reducing agents such as DTT or β-mercaptoethanol can cleave and separate the biotinylated molecule-streptavidin complex from the beads instead of harsh elution reagents such as 8M guanidine or SDS detergent after affinity purification. The microspheres are specifically designed and tested for applications in immunoprecipitation, cell sorting, and rapid single-step capture of biotinylated molecules such as DNA, RNA, antibody, or protein from the cell. The interaction between streptavidin (or avidin n) and biotin exhibits one of the highest known non-covalent interactions). Avidin, streptavidin, monomeric avidin, and their analogs have become powerful tools for probes and affinity ligands for various applications in biochemical assays, diagnosis, affinity purification, and drug delivery. Streptavidin is a tetrameric biotin-binding protein that originates from Streptomyces and has a mass of 60,000 daltons. Streptavidin has no carbohydrate and lower pI, giving a lower degree of nonspecific binding, making streptavidin an ideal reagent choice for many detection systems.

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