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Overview
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b-AP15 is a specific inhibitor of the deubiquitinating enzymes Uch37 and Usp14 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome. Treating cells with b-AP15 causes the accumulation of polyubiquitinated proteins, inhibition of proteasomal degradation, upregulation of apoptotic markers and cell death.
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