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Azido-PEG3-acid

Azido-PEG3-acid

Catalog Number:
PTC1441459INV
Mfr. No.:
V12183
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      • Overview

        • Azido-PEG3-acid (N3-PEG3-CH2CH2COOH) is a novel and potent PEG (polyethyleneglycol) analogue used as a PROTAC linker for the synthesis of BI-3663, BI-4216 and BI-0319. As a PEG-based linker, Azido-PEG3-acid is also used as a non-cleavable 3 unit PEG ADC linker for the synthesis of antibody-drug conjugates (ADCs). It is composed of an azido group, PEG spacer, and carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

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      • Properties
        • Categories
          PROTAC Linkers
          CAS Number
          1056024-94-2
          Molecular Formula
          C9H17N3O5
          Molecular Weight
          247.25
          Purity
          ≥98%
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
          Shipping
          Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
          SMILES
          N(CCOCCOCCOCCC(O)=O)=[N+]=[N-]

          * For research use only

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