Name: Azelaoyl-PAF
Price: Inquiry

- Overview
  - Azelaoyl PAF is a potent PPARγ (Peroxisome proliferator- activated receptor gamma) agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF was isolated as one of a number of low MW species in oxidized low-density lipoprotein (oxLDL) which promoted the differentiation of monocytes. PPAR-gamma agonists like Azelaoyl PAF could play a role in the treatment of neurodegenerative disease Friedreichs ataxia.
    
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- Properties
  - Categories
    
    Ligands of Nuclear Receptors
    
    Alternative Name
    
    1-O-hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine
    
    CAS Number
    
    354583-69-0
    
    Molecular Formula
    
    C33H66NO9P
    
    Molecular Weight
    
    651.85 g/mol
    
    MDL Number
    
    MFCD03412018
    
    Note
    
    There is a hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Davies et al (2001). Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. The Journal of biological chemistry, 276(19), 16015–16023.
    Marmolino et al (2009). PPAR-gamma agonist Azelaoyl PAF increases frataxin protein and mRNA expression: new implications for the Friedreichs ataxia therapy. Cerebellum (London, England), 8(2), 98–103.

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