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GW 6471

GW 6471

Catalog Number:
L002372636APE
Mfr. No.:
APE-B7797
Price:
$349
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      • Overview

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          Background

          PPARα antagonist (IC50 = 0.24 μM). Enhances the binding affinity of the PPARα ligand-binding domain to the co-repressor proteins SMRT and NCoR.

      • Properties
        • Categories
          PPARα antagonist
          Alternative Name
          (S,Z)-N-(3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)-2-((4-oxo-4-(4-(trifluoromethyl)phenyl)but-2-en-2-yl)amino)propyl)propionamide
          CAS Number
          880635-03-0
          Molecular Formula
          C35H36F3N3O4
          Molecular Weight
          619.67
          Appearance
          A crystalline solid
          Purity
          98.00%
          Solubility
          Soluble in DMSO
          Storage
          Store at -20°C
          SMILES
          CC1=C(N=C(C2=CC=CC=C2)O1)CCOC3=CC=C(C[[email protected]](N/C(C)=C\C(C4=CC=C(C(F)(F)F)C=C4)=O)CNC(CC)=O)C=C3

          * For Research Use Only

      • Reference

        • 1. Xu N, Wang Q, et al. "Fenofibrate improves vascular endothelial function and contractility in diabetic mice." Redox Biol. 2018 Oct 1;20:87-97. PMID:30296701
          2. Wang L, Xie H, et al. "rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-α Signaling Pathway." Theranostics. 2017 Aug 15;7(14):3446-3460. PMID:28912887

    Documents

    COA (Certificate Of Analysis)

    MSDS (Material Safety Data Sheet)

    Datasheet

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