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Overview
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Include 3D stretch to your barrier models to mimic the motion of the organ of your choice with the AXBarrier-on-Chip System. Highly compatible with standard laboratory equipment, the technology can be transferred to your lab with minimal effort.
Key Features
The AXBarrier-on-Chip System includes customizable stretch parameters to replicate mechanical cues of any organ barrier.
• Uni- or Bidirectional membrane movement
Create any motion pattern of your choice
• Physiological and Pathophysiological stretch levels
Create physiological motion or simulate traumas / injuries
• Frequency adjustments
Speed up or slow down the motion to target the desired stimuli
• Active and dormant time periods definition
Tune the organ motion to account for day and night activity
• Ultrathin, porous and elastic membrane for cell growth
Thickness: 3.5µm & Pores: Ø 3µm
• Mono- or Coculture models
with/without immune componentPlease contact us at for specific academic pricing.
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- Properties
- Applications
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Overview
The AX12 is based on a 96-well plate format and consists of two chips supported by a plate. This two-part design enables the seeding of the cells directly on either side of the ultrathin membrane. Each chip includes six independent units, allowing for up to 12 samples per AX12. It is compatible with live-cell and high-resolution imaging, as well as standardized read-outs such us TEER, ELISA, rtPCR and flow cytometry.
The AXDock connects the AX12 with the AXBreather and the AXExchanger. Two AXDock units are supplied with the system: one is installed in the incubator and the other is placed inside the cell culture hood. The AX12 is placed inside the AXDock to create an air-tight sealing, ensuring proper pneumatic function.
The AXExchanger is connected to the AXDock inside the cell culture hood. It pneumatically controls the valves of the AX12, located between the inlet well, the cell culture chamber and the outlet well. By opening and closing the valves, a controlled fluid flow is created for initial chip filling and medium exchange. The AXExchanger also allows the measurement of TEER in combination with a suitable equipment. It is operated via a touch screen interface and an intuitive software.
The AXActuator is connected to the second AXDock placed in the incubator. It pneumatically controls the movement of the membrane inside the AX12, recreating the cyclic stretch motion. The parameters can be easily modified in the interface. The AXActuator is controlled via a touch screen interface and an intuitive software. Experimental data can be exported to a USB flash drive for documentation.
AX Barrier-on-Chip System
AX Barrier-on-Chip System
Catalog Number:
CCS1559248ALV
Mfr. No.:
AX-Barrier-on-Chip System
Price:
$8,431
Size:
Each
Quantity:
Add to Cart:
.