L-Alanyl-L-Glutamine

- Overview
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    Background
    
    L-Alanyl-L-glutamine is a stable, water-soluble dipeptide comprised of L-glutamine and L-alanine. L-Alanyl-L-glutamine is used as a nutritional supplement with potential protective and absorption enhancing activities. After oral or enteral administration, L-alanyl-L-glutamine works locally in the gastrointestinal tract, protecting the integrity of the intestinal mucosa and maintaining intestinal barrier functions. This reduces bacterial translocation, infection risk, as well as infection-associated symptoms including diarrhea, malabsorption, dehydration, as well as electrolyte imbalances. L-Alanyl-L-glutamine also increases absorption of other chemicals such as L-glutamine. In addition, L-alanyl-L-glutamine has been shown to benefit the antioxidant system, attenuate inflammation, and modulate the heat shock protein response in catabolic situations.
    
    1. National Center for Biotechnology Information (2021). PubChem Compound Summary for CID 123935, l-Alanyl-l-glutamine. Retrieved September 6, 2021.
    2. Harris RC, Hoffman JR, Allsopp A, et al. L-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat protein. Nutrition Research, 2012, 32(4): 272-277.
    3. Cruzat VF, Keane KN, Scheinpflug AL, et al. Alanyl-glutamine improves pancreatic β-cell function following ex vivo inflammatory challenge. Journal of Endocrinology, 2015, 224(3): 261-271.
- Properties
  - Categories
    
    A synthetic glutamine dipeptide, used as a nutritional supplement
    
    Alternative Name
    
    Ala-Gln,L-Ala-L-Gln; (S)-5-amino-2-((S)-2-aminopropanamido)-5-oxopentanoic acid
    
    CAS Number
    
    39537-23-0
    
    Molecular Formula
    
    C8H15N3O4
    
    Molecular Weight
    
    217.22
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in DMSO; insoluble in EtOH; ≥56.6 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    NC(CC[[email protected]](N(C([[email protected]@H](N)C)=O)[H])C(O)=O)=O
    
    * For Research Use Only

Documents

COA (Certificate Of Analysis)

MSDS (Material Safety Data Sheet)

L-Alanyl-L-Glutamine

Background

Documents

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