Name: β-Apo-oxytetracycline, EvoPure®
Price: 417.00 USD

- Overview
  - β-Apo-oxytetracycline, EvoPure® (oxytetracycline-related compound E) is an oxytetracycline metabolite and impurity found in commercial oxytetracycline. It is formed via acid hydrolysis of oxytetracycline, but unlike other oxytetracycline metabolites, β-apo-oxytetracycline formation does not appear to be influenced by pH; however, it does form more rapidly with increasing temperature. β-Apo-oxytetracycline can be used as a QC standard during stability studies of oxytetracycline. It can be also be used to study the degradation pathway and products of tetracyclines. β-Apo-oxytetracycline, EvoPure® is very slightly soluble in water.
    
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    Background
    
    Oxytetracycline causes inhibition of protein synthesis. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome.
- Properties
  - CAS Number
    
    18751-99-0
    
    Molecular Formula
    
    C22H22N2O8
    
    Molecular Weight
    
    442.42
    
    Appearance
    
    Yellow powder
    
    Solubility
    
    Soluble in basic solutions. Very slightly soluble in water (0.2 mg/ml).
    
    Other Properties
    
    Source: Semi-synthetic
    Melting Point: >160°C
    Purity Level: ≥90.0%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Broad-spectrum, including Gram-negative and Gram-positive bacteria.
    
    Microbiology Applications: The fate of tetracyclines and their degradation products were studied under pH, chelation, and photodegradation. Studied whether they were potent to environmentally relevant sludge and soil bacteria. Tetracyclines photodecompose easily because they undergo direct photolysis and are converted to several products. MIC50 was 32 mg/L for tetracycline-sensitive strains of Pseudomonas, and > 32 mg/L for tetracycline-sensitive strains of Agrobacterium, Bacillus, E. coli. and Moraxella (Halling-Sorenson et al, 2002).