α-Apo-Oxytetracycline, EvoPure®

- Overview
  - α-Apo-Oxytetracycline, EvoPure® (Oxytetracycline-related compound D) is an oxytetracycline metabolite and impurity found in commercial oxytetracycline. It is formed via acid hydrolysis of oxytetracycline. As an isomer of β-Apo-oxytetracycline, it forms readily in acidic and basic media. This highly pure metabolite can be used as a secondary reference standard during stability studies of oxytetracycline and can be used to study the degradation pathway and products of tetracyclines.
    α-Apo-Oxytetracycline, EvoPure® is very slightly soluble in water.
    
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    Background
    
    Oxytetracycline causes inhibition of protein synthesis. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome.
- Properties
  - CAS Number
    
    18695-01-7
    
    Molecular Formula
    
    C22H22N2O8
    
    Molecular Weight
    
    442.42
    
    Solubility
    
    Very slightly soluble (0.2 mg/mL) in water
    
    Other Properties
    
    Source: Semi-synthetic
    Purity Level: >97.0%
    
    Storage
    
    -20°C
    
    * For research use only
- Applications
  - Application Description
    
    Spectrum: Broad-spectrum, including Gram-negative and Gram-positive bacteria.
    
    Microbiology Applications: The fate of tetracyclines and their degradation products were studied under pH, chelation, and photodegradation. Tetracyclines photodecompose easily because they undergo direct photolysis and are converted to several products. Their potency to environmentally relevant sludge and soil bacteria is also a subject of investigation.