Apigenin (from Matricaria recutita)

Apigenin (from Matricaria recutita) is a natural occurring, ubiquitous, low molecular weight plant flavone with low toxicity and is the most bioactive of the plant flavones. It belongs to the flavonoid subclass and has antioxidant, anticancer, immunomodulatory, and anti-inflammatory properties. M. recutita (chamomile) is a medicinal plant containing more than 120 chemical metabolites and Apigenin has been reported to be a biomarker of M. recutita. The name Apigenin is derived from the Apium genus in the Apiaceae family. Apigenin affects several critical pathways and/or targets which are associated with several health disorders including cancer.
Apigenin is soluble in organic solvents such as ethanol, DMSO and DMF but sparingly soluble in aqueous buffers.

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Background

Apigenin exerts a broad range of molecular signaling effects.
Apigenin is an ornithine decarboxylase inhibitor, which is involved in tumor growth and production. Polyphenols may affect the molecular events involved in initiation, promotion, and progression stages of carcinogenesis.
Apigenin also has been shown to inhibit nitric oxide synthase-2 and cyclooxygenase-2 activity in mouse macrophages. Apigenin has been shown to increase the intracellular concentration of glutathione, enhancing the endogenous defense against oxidative stress.