Apigenin (from Apium graveolens)

- Overview
  - Apigenin is a natural occurring, ubiquitous, low molecular weight, bioactive plant flavone. It belongs to the flavonoid subclass and has antioxidant, anticancer, and anti-inflammatory properties. Apigenin affects several critical pathways and/or targets which are associated with several health disorders including cancer.
    
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    Background
    
    Apigenin exerts a broad range of molecular signaling effects. Apigenin is an ornithine decarboxylase inhibitor, which is involved in tumor growth and production. Polyphenols may affect the molecular events involved in initiation, promotion, and progression stages of carcinogenesis. Apigenin also has been shown to inhibit nitric oxide synthase-2 and cyclooxygenase-2 activity in mouse macrophages. Apigenin has been shown to increase the intracellular concentration of glutathione, enhancing the endogenous defense against oxidative stress.
- Properties
  - CAS Number
    
    520-36-5
    
    Molecular Formula
    
    C15H10O5
    
    Molecular Weight
    
    270.24
    
    Appearance
    
    Light yellow powder
    
    Other Properties
    
    Assay (HPLC): Not less than 98.0%
    Loss on Drying: Not more than 2.0%
    
    Storage
    
    ≤30°C
    
    * For research use only
- Applications
  - Application Description
    
    Eukaryotic Cell Culture Applications: A number of the biological effects of Apigenin in numerous in vitro and in vivo mammalian systems are related to its antioxidant effects and its role in scavenging free radicals. It exhibits anti-mutagenic, anti-inflammatory, and antiviral effects (Yang et al, 2001).
    Apigenin has been shown to possess anti-mutagenic properties in a setting of nitropyrene-induced genotoxicity in CHO cells. (Kuo et al, 1992).
    Apigenin exerts its effects on the cell cycle. Exposure of a wide array of malignant cells, including epidermal cells and fibroblasts to apigenin induced a reversible G2/M and G0/G1 arrest by inhibiting p34 (cdc2) kinase activity, accompanied by increased p53 protein stability (Plaumann et al, 1996).
    Apigenin has been reported to inhibit protein kinase C activity, mitogen activated protein kinase (MAPK), transformation of C3HI mouse embryonic fibroblasts and the downstream oncogenes in v-Ha-ras-transformed NIH3T3 cells (Lee et al, X)
    Apigenin promotes chelation of metals, and scavenges free radicals in both in vitro and in vivo tumor models (Middleton et al, 2000).
    
    Cancer Applications: There is considerable potential for Apigenin to be developed as a cancer chemopreventive agent.
    Apigenin has shown promise in inhibiting tumor cell invasion and metastases by regulating protease production (Lindenmeyer et al, 2001).

Datasheet

MSDS

Apigenin (from Apium graveolens)

Apigenin (from Apium graveolens)

Background

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