Antibody Deruxtecan Conjugation Kit (0.1 mg) with Val-Ala Linker

Deruxtecan is an exatecan-derivative topoisomerase I inhibitor (DXd) featuring an enzymatically cleavable peptide linker, GGFG (Nakada, T. et al. Bioorg. Med. Chem. Lett. 2016, 26, 1542−1545). The user supplies the antibody. The kit includes Deruxtecan with a maleimide active group, which can be directly coupled to the antibody following reduction and alkylation in a single step. The product is then purified to remove any unreacted drugs.

Kit is designed to conjugate 1-3 mg of a single antibody sample (CM11431x1) or three antibody samples (CM11431x3).

If you have a smaller amount of IgG, a non-IgG type antibody, or other customization needs, please select the customization radio button and/or fill out the information above.

Antibody Loading
Due to the unknown characteristics of many customers’ antibodies, this kit is designed to attach an average of 4 molecules of deruxtecan to each antibody molecule. Trastuzumab Deruxtecan, sold under the brand name Enhertu, has an average of 8 deruxtecan molecules attached per antibody. If your target is 8 and you have not observed significant aggregation or precipitation with your antibody using this kit, you can go ahead and use CM11434 (Antibody Deruxtecan High Loading Conjugation Kit) for higher loading.

Drug Information
Name: Deruxtecan (Mc-GGFG-DXd)
Synonym: Exatecan derivative, DX 8951 derivative; DXd; payload for DS-8201a
CAS number: 1599440-13-7
Chemical formula: C52H56FN9O13
MW: 1034.0684
Mechanism of action: Trastuzumab Deruxtecan, sold under the brand name Enhertu was approved by US FDA for treating metastatic HER2-postive breast cancer.

Requirement for Antibody
Preferably >90% pure by gel electrophoresis
Total amount: 1-3 mg of protein content as measured by UV.

Key Features of this PerKit™
• Simple and efficient labeling of IgG with Deruxtecan, minimizing toxin exposure.
• Features enzymatic cleavable GGFG peptide linker.
• Delivers an average of 4 Deruxtecan molecules per antibody.
• Fast preparation: 4 hours total, with less than 1 hour of hands-on time.
• Includes all necessary reagents and supplies for preparation and purification.
• Achieves over 95% conjugation, free from unreacted drugs.
• Post-conjugation services are available for analysis and DAR determination.

Please contact us at for specific academic pricing.