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Overview
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Recognizes human vitronectin. Vitronectin is an abundant glycoprotein (~75 kDa), consistingof 459 amino acids. About one third of the protein molecular mass is composed of carbohydrates.Vitronectin is found in blood plasma and the extracellular matrix. Vitronectin is a multifunctionalprotein, since it promotes attachment and spreading of animal cells in vitro, it inhibits cytolysis by thecomplement C5b-9 complex, and it modulates antithrombin III thrombin action in blood coagulation.The protein consists of three domains: the N-terminal Somatomedin B domain (1-39), a central domainwith hemopexin homology (131-342) and a C-terminal domain (347-459) also with hemopexinhomology. The Somatomedin B domain binds to Plasminogen Activator Inhibitor-1 (PAI-1) and isresponsible for PAI-1 stabilization. Furthermore, the Somatomedin B domain can also interact with theurokinase plasminogen activator receptor (uPAR). Vitronectin-uPAR interaction is required andsufficient to initiate downstream changes in cell morphology, migration and signal transduction. binds to soluble vitronectin as well as to membrane bound vitronectin.
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