Name: Anti-Ubiquitin antibody
Price: 345.00 USD

Overview
- Ubiquitin is a highly conserved and plays an essential role in the ubiquitin‐proteasome pathway. In ubiquitination process, it is first activated by forming a thiol‐ester complex with the activation component E1, which is then transferred to ubiquitin‐carrier protein E2, followed by to ubiquitin ligase E3 for final delivery to epsilon‐NH2 of the target protein lysine residue. IkB, p53, cdc25A, Bcl‐2 etc. are shown as targets of ubiquitin‐proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis. Moreover, ubiquitin have been reported to bind covalently with pathological inclusions which are resistant to degradation e.g. neurofibrillary tangles/paired helical filaments in Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease etc.
  
  Please contact us at for specific academic pricing.
Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG2a kappa
  
  Reactivity
  
  human
  
  Clone
  
  ZM191
  
  Immunogen
  
  Recombinant human Ubiquitin protein fragment (around aa 1‐119)
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  * For research use only