Name: Anti-AMACR+p63 antibody
Price: 438.00 USD

Overview
- AMACR is an essential enzyme in the b‐oxidation of branched‐chain fatty acids. High expression of AMACR protein is found in prostate adenocarcinoma but not in benign prostate tissue by immunohistochemical staining in paraffin‐embedded tissue.The expression of AMACR is also detected in prostate premalignant lesions, such as prostate intraepithelial neoplasia (PIN). The p63 protein, a homologue of the tumor‐suppressor p53, is highly expressed in the basal or progenitor layer of many epithelial tissues. P63 is detected in prostate basal cells in normal prostate glands and PIN. However, it is negative in prostate adenocarcinoma. Thus p63 is useful as a differential marker for benign prostate glands and adenocarcinoma (negative marker). The combination of AMACR and p63 may be extremely useful for diagnosing PIN and small focus adenocarcinoma, especially in difficult cases and cases with limited tissues. AMACR stains cytoplasm in prostate adenocarcinoma and PIN while p63 stains basal cell nuclei in PIN and benign prostate glan
  
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Properties
- Host
  
  rabbit; mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG; IgG1a kappa
  
  Reactivity
  
  human
  
  Clone
  
  13H4 + 4A4
  
  Immunogen
  
  Human AMACR (P504S) and p63 polypeptides
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  Antigen
  
  Alpha-Methylacyl-Coa Racemase; 2-Methylacyl-Coa Racemase (Gene ID:23600; UniProt:Q9UHK6)
  
  * For research use only