Name: Anti-SOX10 antibody
Price: 334.00 USD

Overview
- Sry‐related HMG‐BOX gene 10, (SOX‐10), a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage, has been recently shown to be a sensitive marker of melanoma. SOX‐10 nuclear expression was found in virtually all cases of melanomas (97%) and about half of cases of malignant peripheral nerve sheath tumors (49%). In sentinel node, SOX‐10 is positive in metastatic melanomas and nodal capsular nevus but not in dendritic cells, which usually express S100 protein. SOX‐10 is moderately to strongly positive in desmoplastic or spindle cell melanomas, which is usually negative for HMB‐45, Melan‐A or even S‐100. SOX‐10 is diffusely expressed in schwannomas, neurofibromas, sustentacular cells of pheochromocytomas and paragangliomas. SOX‐10 reaction is not identified in any other mesenchymal and epithelial tumors except for myoepitheliomas and diffuse astrocytomas.
  
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Properties
- Host
  
  mouse
  
  Antibody Type
  
  monoclonal
  
  Isotype
  
  IgG2b kappa
  
  Reactivity
  
  human
  
  Clone
  
  ZM10
  
  Immunogen
  
  Recombinant human SOX10 protein fragment (around aa115‐269)
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
  
  Storage
  
  Store at 2-8°C for up to 1 year
  
  Regulatory Status
  
  RUO
  
  * For research use only