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Overview
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SOX2 is a member of the SRY‐related HMG‐box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem‐cell maintenance in the central nervous system, and also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression.SOX‐2 is expressed in teratoma and CNS astrocytic tumors.
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