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Overview
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This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
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Overview
Immunofluorescence analysis of MCF-7 cells using RTKN antibody (STJ115312). Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using RTKN antibody (STJ115312) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 90s.
Anti-RTKN antibody
Anti-RTKN antibody
Catalog Number:
A001022209STJ
Mfr. No.:
STJ115312
Price:
$297
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