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Anti-Receptor-Interacting Serine/Threonine-Protein Kinase (RIP). IgG fraction (monoclonal)

Anti-Receptor-Interacting Serine/Threonine-Protein Kinase (RIP). IgG fraction (monoclonal)

Catalog Number:

A001277480AUS

Mfr. No.:

AUST_MR-1201-4; AUST_MR-1201-7

Price:

$520

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Quantity:

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- Overview
  - IgG fraction from mouse monoclonal antibody (clone 9G11/G4) obtained by immunization of mice with the recombinant N-terminal region of RIP (aa1 - aa430). The IgG fraction was purified using Protein G-Sepharose.
    
    Please contact us at for specific academic pricing.
- Properties
  - Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG2b
    
    Formulation
    
    Solution at 1.0 mg/mL in PBS
    
    Storage
    
    Store at -20°C.
    
    * For research use ONLY in laboratory animals and in vitro testing. NOT for diagnostic or human use.
- Applications
  - Application Description
    
    This antibody can be used for ELISA assay (1:8,000 dilution) and Western Blot (1: 12,000 dilution). RIP is a serine/threonine kinase, component of the active TNF receptor 1 signaling complex. It contains three domains, including an N-terminal kinase domain (aa1 – aa300), an intermediate domain, and a C-terminal death domain. This protein is essential in DNA damage-induced NF-?-B activation and in TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis signaling.
- Reference
  - Meylan, E. et. al. (2004) Nat. Immunol. 5, 503 - 507.
    Zhang, H-G. et. al. (2004) Oncogene 23, 2009 - 2015.
    Hur, G.M. et. al. (2003) Genes & Dev. 17, 873 - 88
    Hsu, H. et. al. (1996) Immunity 4, 387 - 386.

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